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KMID : 0367320130240040207
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Journal of the Korean Academy of Child and Adolescent Psychiatry
2013 Volume.24 No. 4 p.207 ~ p.212
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Long-Term Tolerability of Escitalopram in Korean Adolescents
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Goo Ae-Jin
Won Eun-Kyung
Lee Cheol-Soon
Lee Jong-Il
Jung Hee-Yeon
Kim Ye-Ni
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Abstract
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Objectives : We investigated the long-term tolerability of escitalopram in Korean adolescents.
Methods : The subjects were 37 adolescents, who had been diagnosed with depressive disorder in accordance to DSM-IV. Clinical effectiveness was assessed by Clinical Global Impression-Improvement (CGI-I) scale at the final follow-up visit. Tolerability was assessed through a medical record of the reason for discontinuation of escitalopram and documented adverse events.
Results : The mean duration of treatment was days, and the mean dosage was mg/day. Out of the total 37 patients, two (5%) patients sustained use of escitalopram. Twelve patients (32.4%) discontinued use of escitalopram due to target symptom remission, and 23 patients (61.9%) due to insufficient efficacy. Six patients (16.2%) had at least one documented adverse event. However, no suicidal ideation or self-injurious behavior was reported. Significant differences in clinical symptom improvement efficacy were seen between the patients who were receiving escitalopram for less than 8 weeks (4.3%, 1/13) and those for more than 8 weeks (92.9%, 13/14). There was no significant difference between the tolerability of monotherapy compared to the concomitant use group.
Conclusion : The results of this study suggest that long-term use of escitalopram may result in superior efficacy than shortterm use, and is tolerable in Korean adolescents with depression.
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KEYWORD
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Adolescents, Depression, Escitalopram, Tolerability
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